2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B1836S
    Meldonium-d3 98%
    Meldonium-d3 is the deuterated form of Meldonium. Meldonium is a cardiovascular protective agent that competitively inhibits BBOX1 and OCTN2. The IC50 value of Mildronate against human recombinant BBOX is 34-62 μM, and the EC50 value against human OCTN2 is 21 μM. Meldonium is a fatty acid oxidation inhibitor.
    Meldonium-d3
  • HY-B2236S
    DL-Lysine-d4 dihydrochloride 284664-88-6 99.75%
    DL-Lysine-4,4,5,5-d4 (dihydrochloride) is the deuterium labeled DL-Lysine. DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
    DL-Lysine-d4 dihydrochloride
  • HY-D0885A
    Sodium creatine phosphate dibasic tetrahydrate 71519-72-7 ≥98.0%
    Phosphocreatine disodium tetrahydrate, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction.
    Sodium creatine phosphate dibasic tetrahydrate
  • HY-D0980A
    Biotin-DADOO TFA 194920-57-5
    Biotin-DADOO TFA is a biotinylating reagent. Biotin-DADOO TFA is conjugated to CMC thiosulfate. Biotin-DADOO TFA can be used to synthesize biotin-estradiol conjugates for the determination of plasma estradiol concentrations by enzyme immunoassay.
    Biotin-DADOO TFA
  • HY-E70033
    D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP)
    D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP) is a member of CAZy glycoside hydrolase GH112 family, is often used in biochemical studies. D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP) catalyses the phosphorolysis of lacto-n-biose and galacto-n-biose, to produce Gal-1-P and the corresponding N-acetyl-D-hexosamine.
    D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP)
  • HY-E70040
    Endoglycoceramidase I (EGCase I) 2768502-40-3
    Endoglycoceramidase I (EGCase I) is a glycosidase, is often used in biochemical studies. Endoglycoceramidase I catalyzes a transglycosylation reaction, which transfers the sugar moiety of GSLs to the primary hydroxyl group of several 1-alkanols.
    Endoglycoceramidase I (EGCase I)
  • HY-E70042
    Nucleoside hydrolase (IAGNH) 9025-44-9
    Nucleoside hydrolase (IAGNH) is a glycosidase. Nucleoside hydrolase (IAGNH) catalyzes the cleavage of the N-glycosidic bond in nucleosides to enable the recycling of the nucleobases and Rib.
    Nucleoside hydrolase (IAGNH)
  • HY-E70043
    Ganglioside sialidase (AuSialidase S) 2170331-76-5
    Ganglioside sialidase (AuSialidase S) is an endogenous metabolite. Ganglioside sialidases have been implicated in neuronal differentiation processes, including neurite outgrowth.
    Ganglioside sialidase (AuSialidase S)
  • HY-E70044
    beta-1, 3-N-Acetylhexaminyltransferase (LgtA) 37277-64-8
    beta-1, 3-N-Acetylhexaminyltransferase (LgtA) is a glycosyltransferase, is often used in biochemical studies. beta-1, 3-N-Acetylhexaminyltransferase (LgtA) catalyzes the transfer of N-acetylglucosamine from UDP-GlcNAc to N-acetyllactosamine and lactose.
    beta-1, 3-N-Acetylhexaminyltransferase (LgtA)
  • HY-E70062
    α-2,3-Sialyltransferase, pasteurella multocida 71124-51-1
    alpha-2,3-Sialyltransferase (PmST3) (EC 2.4.99.4) is a beta-galactoside. alpha-2,3-Sialyltransferase (PmST3) catalyzes the transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids.
    α-2,3-Sialyltransferase, pasteurella multocida
  • HY-E70082
    Fructosyl amino acid oxidase 109603-58-9
    Fructosyl amino acid oxidase can be used to measure glycosylated protein. Glycosylated protein, especially glycosylated hemoglobin A1c, is an important marker to evaluate the efficacy of diabetes treatment.
    Fructosyl amino acid oxidase
  • HY-E70132
    Endo-β-N-acetylglucosaminidase D 37278-88-9
    Endo-β-N-acetylglucosaminidase D (Endo D), isolated from Streptococcus pneumoniae. Endo-β-N-acetylglucosaminidase D hydrolyzes Fc N-glycan of intact IgG antibodies after sequential removal of the sialic acid, galactose, and internal GlcNAc residues in the N-glycan. Endo-β-N-acetylglucosaminidase D possesses transglycosylation activity with sugar oxazoline as the donor substrate.
    Endo-β-N-acetylglucosaminidase D
  • HY-E70267
    22:0 Coenzyme A triammonium 799812-95-6
    22:0 Coenzyme A triammonium is a derivative of coenzyme A (CoA), where CoA is combined with a 22-carbon saturated fatty acid (behenic acid, also known as docosanoic acid). 22:0 Coenzyme A triammonium can serve as a substrate for AmFAR1.
    22:0 Coenzyme A triammonium
  • HY-E70570
    Glutamate decarboxylase 9024-58-2
    Glutamate decarboxylase is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide (CO2). Many gut microbes can metabolize glutamate via their Glutamate decarboxylase in a pyridoxal-5′-phosphate (PLP) dependent manner.
    Glutamate decarboxylase
  • HY-E70571
    Glycylproline dipeptidyl aminopeptidase
    Glycylproline dipeptidyl aminopeptidase is an enzyme that catalyzes the hydrolysis of N-terminal glycylproline from glycylprolyl-β-naphthylamide and glycylproline-β-nitroanilide.
    Glycylproline dipeptidyl aminopeptidase
  • HY-E70919
    Nitrile hydratase, Sinorhizobium meliloti
    Nitrile hydratase, Sinorhizobium meliloti (EC 4.2.1.84) is a mononuclear iron or non-corrinoid cobalt enzyme that catalyse the hydration of diverse nitriles to their corresponding amides.
    Nitrile hydratase, Sinorhizobium meliloti
  • HY-E70964
    Leucine Aminopeptidase(microsomal), Porcine
    Leucine Aminopeptidase(microsomal), Porcine (EC 3.4.11.2) is an enzyme that preferentially catalyze the hydrolysis of leucine residues at the N-terminus of peptides and proteins.
    Leucine Aminopeptidase(microsomal), Porcine
  • HY-N0035R
    Arctigenin (Standard) 7770-78-7 98%
    Arctigenin (Standard) is the analytical standard of Arctigenin. This product is intended for research and analytical applications. Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions.
    Arctigenin (Standard)
  • HY-N0073R
    Sarsasapogenin (Standard) 126-19-2 99.91%
    Sarsasapogenin (Standard) is the analytical standard of Sarsasapogenin. This product is intended for research and analytical applications. Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge, with antidiabetic, anti-oxidative, anticancer and anti-inflamatory activities.
    Sarsasapogenin (Standard)
  • HY-N0094R
    Ipriflavone (Standard) 35212-22-7 99.95%
    Ipriflavone (Standard) is the analytical standard of Ipriflavone. This product is intended for research and analytical applications. Ipriflavone is a synthetic isoflavone derivative used to suppress bone resorption.
    Ipriflavone (Standard)
Cat. No. Product Name / Synonyms Application Reactivity